Scientists have identified a new way to distinguish healthy guts from diseased ones and track how some illnesses progress by measuring how gut bacteria interact with one another. According to a study published in Science, a Rutgers-led team of scientists found that healthy and diseased digestive systems behave like two distinct ecological states, driven not by individual microbes but by how entire bacterial communities compete and cooperate.
“Instead of asking which bacteria are there, we started asking how they are related to other bacteria,” said Juan Bonachela, an assistant professor with the Department of Ecology, Evolution and Natural Resources at the Rutgers School of Environmental and Biological Sciences and a senior author of the study. “That change in perspective allowed us to see health and disease as two fundamentally different states of the gut microbiome.”
To measure how bacterial communities shift between health and disease, the team developed a new metric called the Ecological Network Balance Index, or ENBI, which captures whether microbial communities are dominated by competitive or cooperative interactions. To read the full story.