Please read Dr. Brunetti’s article in Antimicrobial Agents and Chemotherapy titled, “Reno-protective effects of melatonin against vancomycin-related acute kidney injury in hospitalized patients: a retrospective cohort study. “
Vancomycin was introduced into clinical practice in 1956 as a first line of invasive treatment for gram positive infections.Vancomycin is a glycopeptide antibiotic effective against gram-positive infections, including methicillin-resistant Staphylococcus aureus (MRSA). In many severe MRSA infections vancomycin dose adjustment is recommended to achieve area under the curve/minimum inhibitory concentration (AUC/MIC) ratio for better response. However, vancomycin causes acute kidney injury (AKI) with prolonged and higher doses. Initially, the nephrotoxicity and ototoxicity was attributed to the earlier formulations of vancomycin which contained product impurities and were termed as ‘Mississippi mud’. To read the full article.
Reno-protective effects of melatonin against vancomycin-related acute kidney injury in hospitalized patients: a retrospective cohort study. Hong TS, Briscese K, Yuan M, Deshpande K, Aleksunes LM, Brunetti L. Antimicrob Agents Chemother. 2021 Jun 21:AAC0046221. PMID:34152824 DOI: 10.1128/AAC.00462-21 Online ahead of print.