Please read Dr. Shah’s article in the Journal of Biological Chemistry titled, “Tracking the carbons supplying gluconeogenesis“.
The COVID-19 pandemic has created a global crisis that has led to substantial morbidity and mortality and has devastated health systems and economies. In response, the global scientific community has mobilized to seek insights to better understand, limit, and treat this disease. In severe SARS-CoV-2 infection, a complex immunopathology exists that comprises active viral replication and an armed, overactive immune, and inflammatory response. As the burden of type 2 diabetes mellitus (T2DM) grows in the 21st century, the need to understand glucose metabolism heightens. Increased gluconeogenesis is a major contributor to the hyperglycemia seen in T2DM. Isotope tracer experiments in humans and animals over several decades have offered insights into gluconeogenesis under euglycemic and diabetic conditions. This review focuses on the current understanding of carbon flux in gluconeogenesis, including substrate contribution of various gluconeogenic precursors to glucose production. To read the full article.