Please read Dr. Ploss’ article in the Journal of Allergy and Clinical Immunology titled, “Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection.“
The immunological mechanisms driving susceptibility to coronavirus disease 2019 (COVID-19), a recent viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remain elusive. While human patient studies have been instrumental in uncovering immune correlates of severe disease, these studies are fraught with considerable limitations. While studies focusing on patients with mild/moderate infections are limited to immunological sampling of the peripheral blood, bronchioalveolar fluid (BALF), and nasopharynx, postmortem studies provide only a snapshot of diseased lung tissues. Interpretation of human studies is also compounded by several factors, including non-synchronized collection of tissues post-infection, interindividual variability, and co-morbidities. To read the full article.
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Kenney DJ, O’Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Cell Rep. 2022 Apr 19;39(3):110714. PMID: 35421379 PMCID: PMC8977517 DOI: 1016/j.celrep.2022.110714 Epub 2022 Apr 4