2021 Publications
- Identification and characterization of an atypical Gαs-biased β 2 AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis. Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Beidokhti MN, Giulianotti MA, Mafi A, Woo JAA, An SS, Goddard WA III, and Liggett SB. PNAS 2021 Dec 7;118(49):e2026668118. doi: 10.1073/pnas.2026668118. PMID: 34857633
- Severe asthma exacerbations in the United States: Incidence, characteristics, predictors, and effects of biologic treatments. Trevor J, Lugogo N, Carr W, Moore WC, Soong W, Panettieri RA Jr,, Desai P, Trudo F, Ambrose CS. Ann Allergy Asthma Immunol. 2021 Nov;127(5):579-587.e1. doi: 10.1016/j.anai.2021.07.010. Epub 2021 Jul 15. PMID: 34273485.
- Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation. Cao G, Lam H, Jude JA, Karmacharya N, Kan M, Jester W, Koziol-White C, Himes BE, Chupp GL, An SS, Panettieri RA Jr. Am J Respir Cell Mol Biol 2021 Oct 14. Online ahead of print. doi: 10.1165/rcmb.2021-0345OC.PMID: 34648729.
- Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection and vaccination. Datta P, Ukey R, Bruiners N, Honnen W, Carayannopoulos MO, Reichman C, Choudhary A, Onyuka A, Handler D, Guerrini V, Mishra PK, Dewald HK, Lardizabal A, Lederer L, Leiser AL, Hussain S, Jagpal SK, Radbel J, Bhowmick T, Horton DB, Barrett ES, Xie YL, Fitzgerald-Bocarsly P, Weiss SH, Woortman M, Parmar H, Roy J, Dominguez-Bello MG, Blaser MJ, Carson JL, Panettieri RA Jr, Libutti SK, Raymond HF, Pinter A, Gennaro ML. J Immunol Methods. 2021 Oct 8:113165. doi: 10.1016/j.jim.2021.113165. Online ahead of print. PMID: 34634317.
- Development of a novel, pan-variant aerosol intervention for COVID-19. Shoemaker RH, Panettieri RA Jr, Libutti SK, Hochster HS, Watts NR, Wingfield PT, Starkl P, Pimenov L, Gawish R, Hladik A, Knapp S, Boring D, White JM, Lawrence Q, Boone J, Marshall JD, Matthews RL, Cholewa BD, Richig JW, Chen BT, McCormick DL, Gugensberger R, Höller S, Penninger JM, Wirnsberger G. bioRxiv. 2021 Sep 14:2021.09.14.459961. doi: 10.1101/2021.09.14.459961. Preprint. PMID: 34545364.
- Determinants and dynamics of SARS-CoV-2 infection in a diverse population: 6-month evaluation of a prospective cohort study. Horton DB, Barrett ES, Roy J, Gennaro ML, Andrews T, Greenberg P, Bruiners N, Datta P, Ukey R, Velusamy SK, Fine D, Honnen WJ, Yin YS, Pinter A, Brooks A, Tischfield J, Hussain S, Jagpal S, Swaminathan S, Parmar V, Reilly N, Gaur S, Panettieri RA Jr, Carson JL, Blaser MJ. J Infect Dis. 2021 Aug 13:jiab411. doi: 10.1093/infdis/jiab411. Online ahead of print. PMID: 34387310.
- Differing perceptions of asthma control and treatment effectiveness by patients with severe asthma and treating subspecialists in the United States. Panettieri RA Jr, Chipps BE, Moore WC, Soong W, Carr WW, Kreindler JL, O’Quinn S, Trudo F, Ambrose CS. J Asthma. 2021 Aug 10:1-13. doi: 10.1080/02770903.2021.1963766. Online ahead of print. PMID: 34374622.
- Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). George CH, Alexander SPH, Cirino G, Insel PA, Izzo AA, Ji Y, Kendall DA, Panettieri RA, Patel HH, Sobey CG, Stanford SC, Stefanska B, Stephens G, Teixeira M, Ahluwalia A. Br J Pharmacol. 2021 Jul 30. doi: 10.1111/bph.15589. Online ahead of print. PMID: 34328225.
- Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling. Sharma P, Yadav SK, Shah SD, Javed E, Lim JM, Pan S, Nayak AP, Panettieri RA Jr., Penn RB, Kambayashi T, Deshpande DA. Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print. PMID: 34293268.
- Autocrine regulation of airwway smooth muscle contraction by diacylglycerol kinase. Yadav SK, Sharma P, Shah SD, Panettieri RA, Kambayashi T, Penn RB, Deshpande DA.J Cell Physiol. 2021 Jul 18. doi: 10.1002/jcp.30528. Online ahead of print. PMID: 34278583.
- Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection. Datta P, Ukey R, Bruiners N, Honnen W, Carayannopoulos MO, Reichman C, Choudhary A, Onyuka A, Handler D, Guerrini V, Mishra PK, Dewald HK, Lardizabal A, Lederer L, Leiser AL, Hussain S, Jagpal SK, Radbel J, Bhowmick T, Horton DB, Barrett ES, Xie YL, Fitzgerald-Bocarsly P, Weiss SH, Woortman M, Parmar H, Roy J, Dominguez-Bello MG, Blaser MJ, Carson JL, Panettieri RA, Libutti SK, Raymond HF, Pinter A, Gennaro ML. medRxiv. 2021 Jul 14:2021.07.09.21260266. doi: 10.1101/2021.07.09.21260266. Preprint. PMID: 34282427.
- Black and Latinx Community Perspectives on COVID-19 Mitigation Behaviors, Testing, and Vaccines. Jimenez ME, Rivera-Núñez Z, Crabtree BF, Hill D, Pellerano MB, Devance D, Macenat M, Lima D, Martinez Alcaraz E, Ferrante JM, Barrett ES, Blaser MJ, Panettieri RA Jr, Hudson SV. JAMA Netw Open. 2021 Jul 1;4(7):e2117074. doi: 10.1001/jamanetworkopen.2021.17074. PMID: 34264327.
- Molecular Nanomechanical Mapping of Histamine-Induced Smooth Muscle Cell Contraction and Shortening. Jo MH, Kim BC, Sung K, Panettieri RA Jr, An SS, Liu J, Ha T. ACS Nano. 2021 Jul 1. doi: 10.1021/acsnano.1c01782. Online ahead of print. PMID: 34197709.
- RGS proteins, GRKs, and beta-arrestins modulate G protein-mediated signaling pathways in asthma. Fuentes N, McCullough M, Panettieri RA Jr, Druey KM. Pharmacol Ther. 2021 Jul;223:107818. doi: 10.1016/j.pharmthera.2021.107818. Epub 2021 Feb 15. PMID 33600853.
- Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells Ramos-Ramírez P, Malmhäll C, Tliba O, Rådinger M, Bossios A. Front Immunol. 2021 May 18;12:677550. doi: 10.3389/fimmu.2021.677550. eCollection 2021. PMID: 34084174.
- Na+/H+ Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite-Induced Asthma. Kammala AK, Bahal D, Yang C, Panettieri RA Jr, Das R, Subramanian H. J Immunol. 2021 May 15;206(10):2301-2311. doi: 10.4049/jimmunol.2001199. Epub 2021 May 5. PMID: 33952618.
- Clinical Outcomes and Health-Care Resource Use Associated With Reslizumab Treatment in Adults With Severe Eosinophilic Asthma in Real-World Practice. Wechsler ME, Peters SP, Hill TD, Ariely R, DePietro MR, Driessen MT, Terasawa EL, Thomason DR, Panettieri RA Jr. Chest. 2021 May;159(5):1734-1746. doi: 10.1016/j.chest.2020.11.060. Epub 2020 Dec 14. PMID: 33333058.
- Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. Sadoff J, Gray G, Vandebosch A, Cárdenas V, Shukarev G, Grinsztejn B, Goepfert PA, Truyers C, Fennema H, Spiessens B, Offergeld K, Scheper G, Taylor KL, Robb ML, Treanor J, Barouch DH, Stoddard J, Ryser MF, Marovich MA, Neuzil KM, Corey L, Cauwenberghs N, Tanner T, Hardt K, Ruiz-Guiñazú J, Le Gars M, Schuitemaker H, Van Hoof J, Struyf F, Douoguih M; ENSEMBLE Study Group. N Engl J Med. 2021 Jun 10;384(23):2187-2201. doi: 10.1056/NEJMoa2101544. Epub 2021 Apr 21. PMID: 33882225.
- Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells. Dong YN, Hsu FC, Koziol-White CJ, Stepanova V, Jude J, Gritsiuta A, Rue R, Mott R, Coulter DA, Panettieri RA Jr, Krymskaya VP, Takano H, Goncharova EA, Goncharov DA, Cines DB, Lynch DR. Sci Rep. 2021 Apr 15;11(1):8205. doi: 10.1038/s41598-021-87667-0. PMID: 33859248.
- Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells. Mishra PK, Bruiners N, Ukey R, Datta P, Onyuka A, Handler D, Hussain S, Honnen W, Singh S, Guerrini V, Yin Y, Dewald H, Choudhary A, Horton DB, Barrett ES, Roy J, Weiss SH, Fitzgerald-Bocarsly P, Blaser MJ, Carson JL, Panettieri RA, Lardizabal A, Chang TL, Pinter A, Gennaro ML.medRxiv. 2021 Apr 14:2021.04.11.21255153. doi: 10.1101/2021.04.11.21255153. Preprint. PMID: 33880486.
- Potential Role of Mast Cells in Regulating Corticosteroid Insensitivity in Severe Asthma Alzahrani A, Hussain A, Alhadian F, Hakeem J, Douaoui S, Tliba O, Bradding P, Amrani Y. Adv Exp Med Biol. 2021 April 1;1303:1-12.
- Glucocorticoid Receptor β (GRβ): Beyond Its Dominant-Negative Function Ramos-Ramírez P, Tliba O. Int J Mol Sci. 2021 Mar 31;22(7):3649.
- Mechanical stress determines the configuration of TGFβ activation in articular cartilage. Zhen G, Guo Q, Li Y, Wu C, Zhu S, Wang R, Guo XE, Kim BC, Huang J, Hu Y, Dan Y, Wan M, Ha T, An S, Cao X. Nat Commun. 2021 Mar 17;12(1):1706. doi: 10.1038/s41467-021-21948-0. PMID: 33731712.
- Targeted Phage Display-based Pulmonary Vaccination in Mice and Non-human Primates.Staquicini DI, Barbu EM, Zemans RL, Dray BK, Staquicini FI, Dogra P, Cardó-Vila M, Miranti CK, Baze WB, Villa LL, Kalil J, Sharma G, Prossnitz ER, Wang Z, Cristini V, Sidman RL, Berman AR, Panettieri RA Jr, Tuder RM, Pasqualini R, Arap W. Med (N Y). 2021 Mar 12;2(3):321-342. doi: 10.1016/j.medj.2020.10.005. Epub 2020 Dec 10. PMID: 33870243.
- PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C. Nat Commun. 2021 Mar 12;12(1):1648. doi: 10.1038/s41467-021-21957-z. PMID: 33712605.
- An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling. Ghosh A, Koziol-White CJ, Jester WF Jr, Erzurum SC, Asosingh K, Panettieri RA Jr, Stuehr DJ. Redox Biol. 2021 Feb;39:101832. doi: 10.1016/j.redox.2020.101832. Epub 2020 Dec 13. PMID: 33360351.
- TGF-β: The missing link in obesity-associated airway diseases? Woo J, Koziol-White C, Panettieri RA Jr., Jude J. Curr Res Pharmacol Drug Discov. 2021 Feb 5;2:100016. doi: 10.1016/j.crphar.2021.100016. eCollection 2021. PMID: 34909651.
