Please read a new publication from Dr. Steven An titled, “PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2“.
Decades of advances in cellular and developmental cardiology have provided fundamental insights into understanding myocardial lineage specification in vivo, and this knowledge has been instrumental for producing cardiomyocytes (CMs) from pluripotent stem cells (PSCs)1,2,3. However, while newborn CMs continue to increase their volume and contractility through extensive morphological, functional, and metabolic changes until adulthood, PSC-derived CMs (PSC-CMs) are mired in an immature state even after long-term culture4,5,6. The lack of maturity significantly limits the scientific and therapeutic applications of PSC-CMs. Furthermore, despite a number of genes involved in CM maturation are associated with cardiomyopathies, little is known about its relevance to the initiation and progression of cardiac pathogenesis6,7. Thus, there is a significant need to understand biological processes underlying CM maturation in vivo. Read the full article.
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C. Nature Communications. 12:1648, 2021.