Please read Dr. Horton’s article in the Journal of Infectious Disease titled, “Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study.“
As the coronavirus disease 2019 (COVID-19) pandemic continues to surge, as of early May 2021, the United States has recorded the most cases (>32 million) and deaths (>580 000) of any country. Approximately one-third of infections are estimated to be asymptomatic and are considered important drivers of viral transmission. Nonetheless, asymptomatic infections may be accompanied by subclinical abnormalities in laboratory tests and lung imaging. Important questions remain about long-term clinical and immunologic consequences of asymptomatic infections. Most persons infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop antibodies against the virus. However, immune responses vary considerably, with a minority of infected people not producing detectable antibodies. The magnitude of humoral immune responses may be proportional to illness severity. To read the full article.
Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study. Horton DB, Barrett ES, Roy J, Gennaro ML, Andrews T, Greenberg P, Bruiners N, Datta P, Ukey R, Velusamy SK, Fine D, Honnen WJ, Yin YS, Pinter A, Brooks A, Tischfield J, Hussain S, Jagpal S, Swaminathan S, Parmar V, Reilly N, Gaur S, Panettieri RA, Carson JL, Blaser MJ. J Infect Dis. 2021 Oct 28;224(8):1345-1356. PMID: 34387310 PMCID: PMC8436370 DOI: 1093/infdis/jiab411