Please read Dr. Dave’s article in Pharmacoepidemiology and Drug Safety titled, “Risk of clinically relevant hyperglycemia with metoprolol compared to carvedilol in older adults with heart failure and diabetes.”
The prevalence of diabetes among older adults is estimated to be greater than 25%, the highest of any age group. Older adults diagnosed with diabetes have higher rates of mortality, reduced functional status, increased risk of institutionalization, and are more likely to develop diabetic complications. The goal of diabetes management—to prevent acute and chronic diabetic complications while minimizing harms—is substantially complicated among older adults due to the high prevalence of multimorbidity, polypharmacy, geriatric syndromes such as frailty and sarcopenia, functional and cognitive impairment, and age-specific physiological changes related to aging that can compromise the adaptive responses to high serum glucose, predisposing them to chronic hyperglycemia. To read the full article.
Risk of clinically relevant hyperglycemia with metoprolol compared to carvedilol in older adults with heart failure and diabetes. Dave CV, Strom BL, Kobylarz FA, Horton DB, Gerhard T, Tseng CL, Dejanovic I, Nyandege A, Setoguchi S.Pharmacoepidemiol Drug Saf. 2021 Jun 8. doi: 10.1002/pds.5303. PMID: 34101945 DOI: 1002/pds.5303