Please read Dr. Horton’s article in Pediatric Allergy and Immunology titled, “Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review.“
Many immune-mediated diseases (IMDs) are rare, but collectively, they affect approximately 5%–8% of Americans. Immune-mediated diseases result from pathologic pathways or responses of the innate or adaptive immune system and include allergic, atopic, autoimmune, and other inflammatory diseases. While the etiology of many IMDs remains unclear, many are thought to arise from a combination of genetic and environmental factors. The gut microbiome, which develops rapidly in early life, plays a crucial role in immune system maturation and function and may be an important mediator of IMDs. Gut dysbiosis and early antibiotic exposure have been linked to reduced immune tolerance and IMD development in children. For example, antibiotics and resultant alterations in gut microbiota have been implicated in the development of asthma and inflammatory bowel disease (IBD). To read the full article.
Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review. Madej J, Atanassova T, McGuire S, Cohen B, Weidner M, Zhang Y, Horton DB. Pediatr Allergy Immunol. 2023 Nov;34(11):e14042. PMID: 38010007 PMCID: PMC10683867 DOI: 1111/pai.14042