nj acts logoPlease read Dr. Neimark’s article in the Journal of Colloid and Interface Science titled, “Adsorption of pulmonary and exogeneous surfactants on SARS-CoV-2 spike protein.

The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) affected over 0.76 billion people worldwide in the last three years, resulting in more than 6.9 million deaths. Novel variants of the virus, such as Omicron and its subvariants, continue to emerge with increased infectivity and vaccine-escape. The continuing pandemic outbreaks have triggered broad research activities aiming at preventing and curing coronavirus diseases. While our understanding of the biochemical structure, pathology, and antibody/drug interactions of SARS-CoV-2 and its variants is rapidly increasing, the physico-chemical aspects of coronavirus interactions with the respiratory system environment remain poorly understood and sparsely addressed. This study aims to bridge this gap by establishing the physico-chemical mechanisms and specifics of surfactant adsorption on SARS-CoV-2 Spike proteins. This work is motivated by the ongoing search for therapeutic exogenous surfactants capable of hindering virion binding to cell receptors. To read the full article.

Adsorption of pulmonary and exogeneous surfactants on SARS-CoV-2 spike protein. Santo KP, Neimark AV. J Colloid Interface Sci. 2023 Nov 15;650(Pt A):28-39. PMID: 37392497 PMCID: PMC10279468 DOI: 1016/j.jcis.2023.06.121 Epub 2023 Jun 19.