Please read Dr. Tao’s article in the Journal of Pain titled, “Injectable PLGA-Coated Ropivacaine Produces A Long-Lasting Analgesic Effect on Incisional Pain and Neuropathic Pain.“
Despite great efforts in research on the control of persistent postsurgical pain during past decades, management of this disorder remains a challenge in a large number of patients. Systemic administration of analgesic drugs (eg, opioids) may cause severe side effects, especially when given repeatedly.Local anesthetics (LA; eg, ropivacaine [RVC]) have been used widely as simple and effective treatment for persistent pain with absent or reduced adverse effects.However, their analgesic effect lasts only several hours after single injection. Given that postsurgical pain may persist for several days, months, and in some cases, even more than 1 year, prolonged, continuous infusions of LA through a catheter implanted near the target nerve tissue are often required, although long-term catheter use is limited due to adverse effects including tissue damage and infection. To read the full article.
Injectable PLGA-Coated Ropivacaine Produces A Long-Lasting Analgesic Effect on Incisional Pain and Neuropathic Pain. Tian X, Zhu H, Du S, Zhang XQ, Lin F, Ji F, Tsou YH, Li Z, Feng Y, Ticehurst K, Hannaford S, Xu X, Tao YX. J Pain. 2021 Feb;22(2):180-195. PMID: 32739615 PMCID:PMC7855452 DOI: 1016/j.jpain.2020.03.009 Epub 2020 Jul 30.