Making decisions in the context of uncertainty is an important hallmark of leadership. Good leadership requires that these decisions be grounded in the scientific evidence that does exist. COVID-19 policies, especially on the reopening of in-person schooling, must be informed by the best available science and evidence, integrated with thoughtful judgment. As a pediatrician and public health researcher well aware of the uncertainties surrounding the management of this pandemic, I feel for the policymakers responsible for these decisions and hope my research can serve them. To read the full story.