2015 Publications

Please listen to Dr. Panettieri’s interview on WPEL with Larry Souder on hydrofracking. https://soundcloud.com/user-8197160…/special-assignment-wpel.

Read Dr. Panettieri’s article Bronchial Thermoplasty: Targeting Structural Cells in Severe Persistent Asthma.

Read Dr. Panettieri’s article in Penn Medicine magazine, Fracking and Public Health: Finding the Best Balance.

Read Dr. Panettieri’s article Functional capacity, health status and inflammatory biomarker profile in a cohort of patients with COPD.

Read Dr. Panettieri’s article MicroRNA-203 negatively regulates c-Abl, ERK1/2 phosphorylation, and proliferation in smooth muscle cells.

Read Drs. Koziol-White & Panettieri’s article Immunostimulatory defective viral genomes from respiratory syncytial virus promote a strong innate antiviral response during infection in mice and humans.

Read Dr. Panettieri’s article Unconventional gas and oil drilling is associated with increased hospital utilization rates.

Read Dr. Panettieri’s article Bronchodilators, receptors and cross-talk: Together is better?

CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. McGeachie MJ, Wu AC, Tse SM, Clemmer GL, Sordillo J, Himes BE, Lasky-Su J, Chase RP, Martinez FD, Weeke P, Shaffer CM, Xu H, Denny JC, Roden DM, Panettieri RA Jr, Raby BA, Weiss ST, Tantisira KG. J Allergy Clin Immunol. 2015 Dec;136(6):1503-1510. doi: 10.1016/j.jaci.2015.04.039. Epub 2015 Jun 12. PMID: 26073756.
Effect of the plant derivative Compound A on the production of corticosteroid-resistant chemokines in airway smooth muscle cells. Gavrila A, Chachi L, Tliba O, Brightling C, Amrani Y. Am J Respir Cell Mol Biol. 2015 Nov;53(5):728-37. doi: 10.1165/rcmb.2014-0477OC. PMID: 25897650.
Bronchial Thermoplasty: Targeting Structural Cells in Severe Persistent Asthma. Panettieri RA Jr. Ann Am Thorac Soc. 2015 Nov;12(11):1593-4. doi: 10.1513/AnnalsATS.201509-627ED. PMID: 26540414.
Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. Hurley PJ, Hughes RM, Simons BW, Huang J, Miller RM, Shinder B, Haffner MC, Esopi D, Kimura Y, Jabbari J, Ross AE, Erho N, Vergara IA, Faraj SF, Davicioni E, Netto GJ, Yegnasubramanian S, An SS, Schaeffer EM. Cancer Res. 2015 Oct 15;75(20):4322-34. doi: 10.1158/0008-5472.CAN-15-0024. Epub 2015 Aug 20. PMID: 26294211.
Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility. Aifuwa I, Giri A, Longe N, Lee SH, An SS, Wirtz D. Oncotarget. 2015 Oct 13;6(31):30516-31. doi: 10.18632/oncotarget.5854. PMID: 26483365.
Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA Jr, Hodinka RL, López CB. PLoS Pathog. 2015 Sep 3;11(9):e1005122. doi: 10.1371/journal.ppat.1005122. eCollection 2015 Sep. PMID: 26336095.
MicroRNA-203 negatively regulates c-Abl, ERK1/2 phosphorylation, and proliferation in smooth muscle cells. Liao G, Panettieri RA, Tang DD. Physiol Rep. 2015 Sep;3(9):e12541. doi: 10.14814/phy2.12541. PMID: 26400984.
Functional capacity, health status, and inflammatory biomarker profile in a cohort of patients with chronic obstructive pulmonary disease. Kohli P, Pinto-Plata V, Divo M, Malhotra A, Harris RS, Lazaar A, Flynn A, Tal-Singer R, Panettieri RA Jr, Celli B. J Cardiopulm Rehabil Prev. 2015 Sep-Oct;35(5):348-55. doi: 10.1097/HCR.0000000000000123. PMID: 26309192.
IFN-γ-induced JAK/STAT, but not NF-κB, signaling pathway is insensitive to glucocorticoid in airway epithelial cells. O’Connell D, Bouazza B, Kokalari B, Amrani Y, Khatib A, Ganther JD, Tliba O. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L348-59. doi: 10.1152/ajplung.00099.2015. Epub 2015 Jun 19. PMID: 26092996
Correction: Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates.Jemielita T, Gerton GL, Neidell M, Chillrud S, Yan B, Stute M, Howarth M, Saberi P, Fausti N, Penning TM, Roy J, Propert KJ, Panettieri RA Jr. PLoS One. 2015 Aug 28;10(8):e0137371. doi: 10.1371/journal.pone.0137371. eCollection 2015. PMID: 26317358.
Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma. Himes BE, Koziol-White C, Johnson M, Nikolos C, Jester W, Klanderman B, Litonjua AA, Tantisira KG, Truskowski K, MacDonald K, Panettieri RA Jr, Weiss ST. PLoS One. 2015 Jul 24;10(7):e0134057. doi: 10.1371/journal.pone.0134057. eCollection 2015. PMID: 26207385.
Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates. Jemielita T, Gerton GL, Neidell M, Chillrud S, Yan B, Stute M, Howarth M, Saberi P, Fausti N, Penning TM, Roy J, Propert KJ, Panettieri RA Jr. PLoS One. 2015 Jul 15;10(7):e0131093. doi: 10.1371/journal.pone.0131093. eCollection 2015. PMID: 26176544.
Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma. Jiang H, Xie Y, Abel PW, Wolff DW, Toews ML, Panettieri RA Jr, Casale TB, Tu Y. Am J Respir Cell Mol Biol. 2015 Jul;53(1):42-9. doi: 10.1165/rcmb.2014-0319OC. PMID: 25368964.
Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB. PLoS One. 2015 Jun 29;10(6):e0131582. doi: 10.1371/journal.pone.0131582. eCollection 2015. PMID: 26121686
Erratum. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Eur Respir J. 2015 Jun;45(6):1763. doi: 10.1183/09031936.50042414. PMID: 26028625.
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.Sharma A, Menche J, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL. Hum Mol Genet. 2015 Jun 1;24(11):3005-20. doi: 10.1093/hmg/ddv001. Epub 2015 Jan 12. PMID: 25586491.
Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma.Gupta MK, Asosingh K, Aronica M, Comhair S, Cao G, Erzurum S, Panettieri RA Jr, Naga Prasad SV. PLoS One. 2015 May 29;10(5):e0125803. doi: 10.1371/journal.pone.0125803. eCollection 2015. PMID: 26023787.
Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development. Yang G, An SS, Ji Y, Zhang W, Pei Y. Oxid Med Cell Longev. 2015;2015:357824. doi: 10.1155/2015/357824. Epub 2015 May 17. PMID: 26075033.
A fungal protease allergen provokes airway hyper-responsiveness in asthma.Balenga NA, Klichinsky M, Xie Z, Chan EC, Zhao M, Jude J, Laviolette M, Panettieri RA Jr, Druey KM. Nat Commun. 2015 Apr 13;6:6763. doi: 10.1038/ncomms7763. PMID: 25865874.
Airway responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimeras. Guedes AG, Jude JA, Paulin J, Rivero-Nava L, Kita H, Lund FE, Kannan MS. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L485-93. doi: 10.1152/ajplung.00227.2014. Epub 2015 Jan 9. PMID: 25575514
CD38 and airway hyper-responsiveness: studies on human airway smooth muscle cells and mouse models.Guedes AG, Deshpande DA, Dileepan M, Walseth TF, Panettieri RA Jr, Subramanian S, Kannan MS. Can J Physiol Pharmacol. 2015 Feb;93(2):145-53. doi: 10.1139/cjpp-2014-0410. Epub 2014 Dec 9. PMID: 25594684.
Bronchodilators, receptors and cross-talk: Together is better? Panettieri RA Jr. Postgrad Med. 2015;127(7):771-80. doi: 10.1080/00325481.2015.1080589. Epub 2015 Aug 19. PMID: 26293997.
Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity.Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Eur Respir J. 2015 Jan;45(1):87-97. doi: 10.1183/09031936.00042414. Epub 2014 Oct 30. PMID: 25359343.
COX-2 dependent regulation of mechanotransduction in human breast cancer cells. Yoon AR, Stasinopoulos I, Kim JH, Yong HM, Kilic O, Wirtz D, Bhujwalla ZM, An SS. Cancer Biol Ther. 2015;16(3):430-7. doi: 10.1080/15384047.2014.1003004. PMID: 25701047.
Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells. Gajula RP, Chettiar ST, Williams RD, Nugent K, Kato Y, Wang H, Malek R, Taparra K, Cades J, Annadanam A, Yoon AR, Fertig E, Firulli BA, Mazzacurati L, Burns TF, Firulli AB, An SS, Tran PT. Neoplasia. 2015 Jan;17(1):16-31. doi: 10.1016/j.neo.2014.10.009. PMID: 25622896.
Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells. Shiraishi T, Verdone JE, Huang J, Kahlert UD, Hernandez JR, Torga G, Zarif JC, Epstein T, Gatenby R, McCartney A, Elisseeff JH, Mooney SM, An SS, Pienta KJ. Oncotarget. 2015 Jan 1;6(1):130-43. doi: 10.18632/oncotarget.2766. PMID: 25426557.

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