Reynold A. Panettieri, Jr, M.D.

Rey Panettieri

Vice Chancellor for Translational Medicine and Science
Director, Rutgers Institute for Translational Medicine and Science
Professor of Medicine, Robert Wood Johnson Medical School
Emeritus Professor of Medicine, University of Pennsylvania

 

Rutgers Institute for Translational Medicine and Science
Child Health Institute of New Jersey
Rutgers, The State University of New Jersey
89 French Street       
New Brunswick, NJ 08901

Office: (732) 235-6404

Fax: (732) 2357178

Email: rp856@ca.rutgers.edu


Education: 
M.D., University of Pennsylvania, Philadelphia, PA

Residency: 
Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship: 
Hospital of the University of Pennsylvania, Philadelphia, PA

Reynold A. Panettieri, Jr, MD, the inaugural Director of the Institute for Translational Medicine and Science and Vice Chancellor for Translational Medicine and Science at Rutgers University, previously served as the Director of the Airways Biology Initiative at the University of Pennsylvania. His interests include the cellular and molecular mechanisms that regulate airway smooth muscle cell growth and the immunobiology of airway smooth muscle. Consequences of increases in airway smooth muscle growth promote the development of irreversible airflow obstruction and airway remodeling seen in patients with chronic severe asthma. Dr. Panettieri’s lab also focuses on cytosolic signaling pathways that mediate gene expression and alter myocyte growth.

Dr. Panettieri also served as the Deputy Director of the Center of Excellence in Environmental Toxicology at the University of Pennsylvania. He directed the human exposure chamber that defines the molecular mechanisms regulating ozone- and particulate matter-induced airway hyperresponsiveness.

In addition to his research and clinical interests, Dr. Panettieri served as chairperson of the NIH Lung Cellular, Molecular, and Immunobiology Study Section, is a member of the NIH Distinguished Editorial Panel, and is a member of the American Society for Clinical Investigation and Association of American Physicians.

Current basic research projects open to fellow participation:

Selected publications

  1. Xie Y., Jiang H., Zhang Q., Mehrotra S., Abel P., Toews M.L., Wolff D.W., Panettieri R.A., Jr., Casale T.B., Tu Y.  Upregulation of RGS2:  A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis.  Resp. Res., accepted for publication.
  2. Koziol-White C.J., Jia Y., Baltus G.A., Cooper P.R., Zaller D.M., Crackower M.A., Sirkowski E.E., Smock S., Alves S.E., Panettieri R.A., Jr.Inhibition of spleen tyrosine kinase attenuates IgE-mediated bronchoconstriction and mediator release in human precision cut lung slices.  Br J Pharmacol. 2016 Jul 15.
  3. Jude J., Koziol-White C., Scala J., Jester W., Maute C., Dalton P., Panettieri R.A., Jr.Formaldehyde induces Rho-associated kinase activity to evoke airway hyperresponsiveness.  Am. J. Respir. Am J Respir Cell Mol Biol. 2016 May 5. [Epub ahead of print]
  4. Sasse SK, Altonsy MO, Kadiyala V, Cao G, Panettieri RA Jr, Gerber AN. Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1 [Epub ahead of print]
  5. Koziol-White C.J., Yoo E.J., Cao G., Zhang J., Papanikolaou E., Puchkarsky I., Andrews A., Himes B., Damoiseaux RD., Liggett S., Di Carlo D., Kurten R., Panettieri R.A., Jr.Inhibition of phosphoinositide 3-kinase (PI3K) promotes bronchodilation of human small airways in a Rho kinase-dependent manner.  Br J Pharmacol. 2016 Jun 28. [Epub ahead of print]
  6. Jude J., Koziol-White C., Scala J., Jester W., Maute C., Dalton P., Panettieri R.A., Jr.Formaldehyde induces Rho-associated kinase activity to evoke airway hyperresponsiveness.  Am. J. Respir. Am J Respir Cell Mol Biol. 2016 May 5. [Epub ahead of print]
  7. Li S., Koziol-White C., Jude J., Jiang M., Cao G., Yoo E., Jester W., Morley M.P., Lu M.M., Panettieri R.A., Jr., Morrisey E.E.: An epithelial-smooth muscle paracrine pathway that induces asthma through ectopic expression of neuropeptide-Y.  J. Clin. Invest., 126(5):1978-82. doi: 10.1172/JCI81389. Epub 2016 Apr 18.
  8. Ghosh A., Koziol-White C.J., Asosingh K., Cheng G., Ruple L., Rodgers J., Groneberg D., Friebe A., Comhair S., Stasch J.-P., Panettieri R.A., Jr., Aronica. M.A., Erzurum S.C., Stuehr D.J.:  Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.  PNAS, 113(17):E2355-62.  Epub 2016 Apr 11.
  9. Dileepan M., Sarver A.E., Rao S.P., Panettieri R.A., Jr., Subramanian S., Kannan M.S.:  MicroRNA mediated chemokine responses in human airway smooth muscle cells.  PLoS One, 11(3):e0150842. eCollection 2016.
  10. An S., Mitzner W., Tang W.Y., Ahn K., Yoon A.R., Huang J., Kilic O., Yong H.M., Fahey J.W., Kumar S., Biswal S., Holgate S.T., Panettieri R.A., Jr., Solway J., Liggett S.B.:  An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma.  J. Allergy Clin. Immunol. Feb 27. pii: S0091-6749(16)00116-0. [Epub ahead of print] 2016.
  11. Panettieri RA Jr.  Bronchial Thermoplasty: Targeting Structural Cells in Severe Persistent Asthma. Ann Am Thorac Soc. 2015 Nov;12 (11):1593-4.
  12. Carr R. III, Koziol-White C., Zhang J., Lam H., An S.S., Tall G.G., Panettieri R.A., Jr., Benovic, J.L.:  Interdicting Gq activation in airway disease by receptor-dependent and receptor-independent mechanisms.  Mol. Pharmacol. 89:94-104, 2016.
  13. Sun Y., Jain D., Genoyer E., Gilbert M., Tapia K., Koziol-White C.J., Panettieri R.A., Jr., Hodinka R.L., Lopez C.B.:  Immunostimulatory defective viral genomes from respiratory syncytial virus promote a strong innate antiviral response during infection in mice and humans.  PLoS Pathogens 11(9):e1005122, 2015.
  14. Jemielita T., Gerton G.L., Neidell M., Chillrud S., Yan B., Stute M., Howarth M., Saberi P., Fausti N., Penning T.M., Roy J., Propert K.J., Panettieri R.A., Jr.Unconventional gas and oil drilling is associated with increased hospital utilization rates.  PLoS One 10(7):e0131093, 2015 Correction: 10(8):e0137371, 2015 .
  15. Kohli P., Pinto-Plata V., Divo M., Malhotra A., Harris R.S., Lazaar A., Flynn A., Tal-Singer R., Panettieri R.A., Jr., Celli B.:  Functional capacity, health status and inflammatory biomarker profile in a cohort of patients with COPD.  J. Cardiopulm. Rehab. Prev. 35:348-355, 2015.