Reynold A. Panettieri, Jr, M.D.

Reynold A. Panettieri, Jr, M.D.

Vice Chancellor for Translational Medicine and Science Director, Rutgers Institute for Translational Medicine and Science Professor of Medicine, Robert Wood Johnson Medical School Emeritus Professor of Medicine, University of Pennsylvania

 

Rutgers Institute for Translational Medicine and Science
Child Health Institute of New Jersey
Rutgers, The State University of New Jersey
89 French Street
New Brunswick, NJ 08901

(732) 235-6404
rp856@rbhs.rutgers.edu

 

Education

M.D., University of Pennsylvania, Philadelphia, PA

Residency

Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship

Hospital of the University of Pennsylvania, Philadelphia, PA
Reynold A. Panettieri, Jr, MD, the inaugural Director of the Institute for Translational Medicine and Science and Vice Chancellor for Translational Medicine and Science at Rutgers University, previously served as the Director of the Airways Biology Initiative at the University of Pennsylvania. His interests include the cellular and molecular mechanisms that regulate airway smooth muscle cell growth and the immunobiology of airway smooth muscle. Consequences of increases in airway smooth muscle growth promote the development of irreversible airflow obstruction and airway remodeling seen in patients with chronic severe asthma. Dr. Panettieri’s lab also focuses on cytosolic signaling pathways that mediate gene expression and alter myocyte growth.

Dr. Panettieri also served as the Deputy Director of the Center of Excellence in Environmental Toxicology at the University of Pennsylvania. He directed the human exposure chamber that defines the molecular mechanisms regulating ozone- and particulate matter-induced airway hyperresponsiveness.
In addition to his research and clinical interests, Dr. Panettieri served as chairperson of the NIH Lung Cellular, Molecular, and Immunobiology Study Section, is a member of the NIH Distinguished Editorial Panel, and is a member of the American Society for Clinical Investigation and Association of American Physicians.
Current basic research projects open to fellow participation:

  • Immunobiology of airway smooth muscle: A major emphasis of our laboratory focuses on the immunobiology of airway smooth muscle (ASM) cells in asthma and chronic obstructive pulmonary disease (COPD). We have characterized that ASM can orchestrate and perpetuate airway inflammation through the secretion of chemokines/cytokines and expression of cell adhesion molecules. We define the critical signaling pathways by which structural cells modulate inflammatory responses, specifically the interplay of nuclear receptors such as vitamin D and glucocorticoids in inhibiting pro-inflammatory signals in mesenchymal cells.
  • Airway smooth muscle growth and airway remodeling: In some but not all patients with asthma, irreversible airflow obstruction occurs that evokes morbidity and mortality. A seminal finding of airway remodeling is increases in ASM mass. Our studies have recently defined that Regulators of G protein coupled Signaling (RGS) modulate ASM contractile responses and promote ASM cell growth. Our studies focus on novel approaches to inhibit ASM growth and maintain the contractile nature of human ASM cells. Specific tools utilize molecular approaches for cell signaling, as well as, novel imaging of cytosolic calcium and confocal bronchoscopy.
  • Environmental health studies and airway smooth muscle cell function: Ozone and other environmental toxins can induce airway hyperresponsiveness. The molecular mechanisms regulating ozone-mediated airway inflammation and airway hyperresponsiveness remain unclear. Our studies have defined novel eicosanoids and prostaglandins that mediate ozone-induced inflammation. Using translational biologic approaches in which a human exposure chamber delivers ozone to well-characterized patients with asthma and COPD, the characteristics of airway hyperresponsiveness and the molecular mechanisms regulating these phenotypes are defined.
  • Novel therapeutic approaches to treat airways diseases: Our laboratory has devoted considerable effort to collaborate with most major pharmaceutical companies to identify novel targets and platforms to test new therapeutic approaches in asthma and COPD. Using precision cut lung slices (PCLS) from humans and mice, the fundamental processes that regulate ASM contraction and growth can be defined, and novel therapeutics to inhibit such processes are characterized.

Selected publications

 

  1. Xie Y., Jiang H., Zhang Q., Mehrotra S., Abel P., Toews M.L., Wolff D.W., Panettieri R.A., Jr., Casale T.B., Tu Y. Upregulation of RGS2: A New Mechanism for Pirfenidone Amelioration of Pulmonary Fibrosis. Resp. Res., accepted for publication.
  2. Koziol-White C.J., Jia Y., Baltus G.A., Cooper P.R., Zaller D.M., Crackower M.A., Sirkowski E.E., Smock S., Alves S.E., Panettieri R.A., Jr.: Inhibition of spleen tyrosine kinase attenuates IgE-mediated bronchoconstriction and mediator release in human precision cut lung slices. Br J Pharmacol. 2016 Jul 15.
  3. Jude J., Koziol-White C., Scala J., Jester W., Maute C., Dalton P., Panettieri R.A., Jr.: Formaldehyde induces Rho-associated kinase activity to evoke airway hyperresponsiveness. Am. J. Respir. Am J Respir Cell Mol Biol. 2016 May 5. [Epub ahead of print]
  4. Sasse SK, Altonsy MO, Kadiyala V, Cao G, Panettieri RA Jr, Gerber AN. Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1 [Epub ahead of print]
  5. Koziol-White C.J., Yoo E.J., Cao G., Zhang J., Papanikolaou E., Puchkarsky I., Andrews A., Himes B., Damoiseaux RD., Liggett S., Di Carlo D., Kurten R., Panettieri R.A., Jr.: Inhibition of phosphoinositide 3-kinase (PI3K) promotes bronchodilation of human small airways in a Rho kinase-dependent manner. Br J Pharmacol. 2016 Jun 28. [Epub ahead of print]
  6. Jude J., Koziol-White C., Scala J., Jester W., Maute C., Dalton P., Panettieri R.A., Jr.: Formaldehyde induces Rho-associated kinase activity to evoke airway hyperresponsiveness. Am. J. Respir. Am J Respir Cell Mol Biol. 2016 May 5. [Epub ahead of print]
  7. Li S., Koziol-White C., Jude J., Jiang M., Cao G., Yoo E., Jester W., Morley M.P., Lu M.M., Panettieri R.A., Jr., Morrisey E.E.: An epithelial-smooth muscle paracrine pathway that induces asthma through ectopic expression of neuropeptide-Y. J. Clin. Invest., 126(5):1978-82. doi: 10.1172/JCI81389. Epub 2016 Apr 18.
  8. Ghosh A., Koziol-White C.J., Asosingh K., Cheng G., Ruple L., Rodgers J., Groneberg D., Friebe A., Comhair S., Stasch J.-P., Panettieri R.A., Jr., Aronica. M.A., Erzurum S.C., Stuehr D.J.: Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. PNAS, 113(17):E2355-62. Epub 2016 Apr 11.
  9. Dileepan M., Sarver A.E., Rao S.P., Panettieri R.A., Jr., Subramanian S., Kannan M.S.: MicroRNA mediated chemokine responses in human airway smooth muscle cells. PLoS One, 11(3):e0150842. eCollection 2016.
  10. An S., Mitzner W., Tang W.Y., Ahn K., Yoon A.R., Huang J., Kilic O., Yong H.M., Fahey J.W., Kumar S., Biswal S., Holgate S.T., Panettieri R.A., Jr., Solway J., Liggett S.B.: An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. J. Allergy Clin. Immunol. Feb 27. pii: S0091-6749(16)00116-0. [Epub ahead of print] 2016.
  11. Panettieri RA Jr. Bronchial Thermoplasty: Targeting Structural Cells in Severe Persistent Asthma. Ann Am Thorac Soc. 2015 Nov;12 (11):1593-4.
  12. Carr R. III, Koziol-White C., Zhang J., Lam H., An S.S., Tall G.G., Panettieri R.A., Jr., Benovic, J.L.: Interdicting Gq activation in airway disease by receptor-dependent and receptor-independent mechanisms. Mol. Pharmacol. 89:94-104, 2016.
  13. Sun Y., Jain D., Genoyer E., Gilbert M., Tapia K., Koziol-White C.J., Panettieri R.A., Jr., Hodinka R.L., Lopez C.B.: Immunostimulatory defective viral genomes from respiratory syncytial virus promote a strong innate antiviral response during infection in mice and humans. PLoS Pathogens 11(9):e1005122, 2015.
  14. Jemielita T., Gerton G.L., Neidell M., Chillrud S., Yan B., Stute M., Howarth M., Saberi P., Fausti N., Penning T.M., Roy J., Propert K.J., Panettieri R.A., Jr.: Unconventional gas and oil drilling is associated with increased hospital utilization rates. PLoS One 10(7):e0131093, 2015 Correction: 10(8):e0137371, 2015 .
  15. Kohli P., Pinto-Plata V., Divo M., Malhotra A., Harris R.S., Lazaar A., Flynn A., Tal-Singer R., Panettieri R.A., Jr., Celli B.: Functional capacity, health status and inflammatory biomarker profile in a cohort of patients with COPD. J. Cardiopulm. Rehab. Prev. 35:348-355, 2015.