Cynthia J. Koziol-White, Ph.D.
Assistant Professor, Department of Pharmacology, Robert Wood Johnson Medical School
Rutgers Institute for Translational Medicine and Science
Child Health Institute of New Jersey
Rutgers, The State University of New Jersey
89 French Street
New Brunswick, NJ 08901
Fax: (732) 235-7178
Ph.D., Molecular and Cellular Pharmacology, University of Wisconsin, Madison, WI
B.S., Biomolecular Science, Clarkson University, Potsdam, NY
University of Pennsylvania, Philadelphia, PA
Dr. Koziol-White joined the laboratory in 2009 and has focused on novel human models of airway disease exacerbations using state-of-the-art molecular, imaging and cell biology methods. Her specific projects focus on the following platforms:
- Viral-induced airway hyperresponsiveness (AHR). Dr. Koziol-White shows that rhino virus 16-induced AHR occurs independently of viral infectivity and immune responses. Her focus is in delineating the contribution of paracrine and autocrine epithelial cell interactions in modulating airway smooth muscle function.
- Molecular mechanisms promoting novel bronchodilator effects in human airway smooth muscle. Dr. Kozio-White showed that phosphoinositide 3-kinase delta inhibition abrogated and/or prevented agonist-induced bronchoconstriction. This signaling pathway is independent of increases in cyclic AMP and protein kinase A activation.
- Understanding mast cell interaction with airway smooth muscle cell function. Dr. Koziol-White showed that Syk activation is required to induce mast cell-dependent bronchoconstriction in airway smooth muscle Other studies focus on the paracrine and autocrine mechanisms that regulate mast cell effects on immune responses.
- Adventitial stromal cells and myofibroblasts recruit pro- and anti-inflammatory immune cells in allergic airway inflammation. Allergy. 2023 May 12. PMID: 37171245 DOI: 10.1111/all.15766
- Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma. Guidi R, Xu D, Choy DF, Ramalingam TR, Lee WP, Modrusan Z, Liang Y, Marsters S, Ashkenazi A, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Leong L, Cook A, Tran TH, Austin CD, Cao Y, Clarke C, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Wang F, Wilson MS.Sci Transl Med. 2022 Apr 20;14(641):eabl8146. doi: 10.1126/scitranslmed.abl8146. Epub 2022 Apr 20. PMID: 35442706.
- Airway smooth muscle and airway hyperresponsiveness in asthma – mechanisms of airway smooth muscle dysfunction Gebski EB, Anaspure O, Panettieri RA,Koziol-White CJ. Minerva Med. 2022 Feb;113(1):4-16. DOI: 10.23736/S0026-4806.21.07283-9. Epub 2021 Jan 26. PMID: 33496164.
- Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma. Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, Hambro Sh, Nunez V, Klementowicz JE, Shi Y, Wang J, Bevers J III, Ramirez-Carrozzi V, Pappu R, Abbas A, Vander-Heiden J, Choy DF, Yadav R, Modrusan Z, Panettieri RA Jr., Koziol-White C, Jester WF Jr., Jenkins BJ, Cao Y, Clarke C, Austin C, Lafkas D, Xu M, Wolters PJ, Arron JR, West NR, Wilson MS. Science Translational Medicine 14, eabf8188 (2022) 12 January 2022.
- Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation. Online ahead of print. doi: 10.1165/rcmb.2021-0345OC.PMID: 34648729.
- Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells Dong YN, Hsu FC, Koziol-White CJ, Stepanova V, Jude J, Gritsiuta A, Rue R, Mott R, Coulter DA, Panettieri RA Jr, Krymskaya VP, Takano H, Goncharova EA, Goncharov DA, Cines DB, Lynch DR. Sci Rep. 2021 Apr 15;11(1):8205. doi: 10.1038/s41598-021-87667-0. PMID: 33859248.
- TGF-β: The missing link in obesity-associated airway diseases? Woo J, Koziol-White C, Panettieri RA Jr., Jude J. Curr Res Pharmacol Drug Discov. 2021 Feb 5;2:100016. doi: 10.1016/j.crphar.2021.100016. eCollection 2021. PMID: 34909651.
- An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling Ghosh A,Koziol-White CJ, Jester WF Jr, Erzurum SC, Asosingh K, Panettieri RA Jr, Stuehr DJ. Redox Biol. 2021 Feb;39:101832. doi: 10.1016/j.redox.2020.101832. Epub 2020 Dec 13. PMID: 33360351.
- The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR Huang J, Lam H, Koziol-White CJ, Limjunyawong N, Kim D, Kim N, Karmacharya N, Rajkumar P, Firer D, Dalesio NM, Jude J, Kurten RC, Pluznick JL, Deshpande DA, Penn RB, Liggett SB, Panettieri RA, Dong X, An SS. . Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28485-28495. doi: 10.1073/pnas.2003111117. Epub 2020 Oct 23. PMID: 33097666.
- Dexamethasone rescues TGF-β1-mediated β2-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells Chung E, Ojiaku CA, Cao G, Parikh V, Deeney B, Xu S, Wang S, Panettieri RA Jr, Koziol-White CJ. Respir Res. 2020 Oct 8;21(1):256. doi: 10.1186/s12931-020-01522-w. PMID: 33032603.