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Institute for Translational Medicine and Science

Home / Faculty / Cynthia J. Koziol-White, Ph.D.

Cynthia J. Koziol-White, Ph.D.

Cynthia J. Koziol-White, Ph.D.

Assistant Professor, Department of Pharmacology, Robert Wood Johnson Medical School

 

Rutgers Institute for Translational Medicine and Science
Child Health Institute of New Jersey
Rutgers, The State University of New Jersey
89 French Street
New Brunswick, NJ 08901

(732) 235-7170
Fax: (732) 235-7178
cjk167@rbhs.rutgers.edu

 

Education

Ph.D., Molecular and Cellular Pharmacology, University of Wisconsin, Madison, WI
B.S., Biomolecular Science, Clarkson University, Potsdam, NY

Postdoctoral Fellowship

University of Pennsylvania, Philadelphia, PA

Dr. Koziol-White joined the laboratory in 2009 and has focused on novel human models of airway disease exacerbations using state-of-the-art molecular, imaging and cell biology methods.  Her specific projects focus on the following platforms:

  • Viral-induced airway hyperresponsiveness (AHR).  Dr. Koziol-White shows that rhino virus 16-induced AHR occurs independently of viral infectivity and immune responses.  Her focus is in delineating the contribution of paracrine and autocrine epithelial cell interactions in modulating airway smooth muscle function.
  • Molecular mechanisms promoting novel bronchodilator effects in human airway smooth muscle.  Dr. Kozio-White showed that phosphoinositide 3-kinase delta inhibition abrogated and/or prevented agonist-induced bronchoconstriction.  This signaling pathway is independent of increases in cyclic AMP and protein kinase A activation.
  • Understanding mast cell interaction with airway smooth muscle cell function.  Dr. Koziol-White showed that Syk activation is required to induce mast cell-dependent bronchoconstriction in airway smooth muscle  Other studies focus on the paracrine and autocrine mechanisms that regulate mast cell effects on immune responses.

Selected Publications

  1.  Editorial for special issue-human precision cut lung slices: an Ex vivo platform for therapeutic target discovery and drug testing in lung disease. Koziol-White CJ, Panettieri RA Jr.Respir Res. 2024 Mar 23;25(1):137. doi: 10.1186/s12931-024-02756-8.PMID: 38521949
  2. Adventitial stromal cells and myofibroblasts recruit pro- and anti-inflammatory immune cells in allergic airway inflammation. Xu E, Cao G, Yang Z, Zhang Y, Si Y, Singh K, Jude J, An SS, Koziol-White CJ, Panettieri RA Jr, Yang Q. Allergy. 2023 May 12. PMID: 37171245 DOI: 10.1111/all.15766
  3. Rhinovirus induces airway remodeling: what are the physiological consequences? Spector C, De Sanctis CM, Panettieri RA Jr, Koziol-White CJ.Respir Res. 2023 Sep 29;24(1):238. doi: 10.1186/s12931-023-02529-9.PMID: 37773065
  4. Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle. Gebski EB, Parikh V, Lam H, Kim N, Bochkov YA, Cao G, Panettieri RA Jr, Kurten R, Gern J, An SS, Koziol-White CJ. Am J Respir Cell Mol Biol. 2023 Aug;69(2):172-181. doi: 10.1165/rcmb.2021-0526OC.PMID: 37098126
  5. A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14. Woo JA, Castaño M, Kee TR, Lee J, Koziol-White CJ, An SS, Kim D, Kang DE, Liggett SB.Am J Respir Cell Mol Biol. 2023 Apr;68(4):417-429. doi: 10.1165/rcmb.2022-0303OC.PMID: 36662576
  6. Epinephrine evokes shortening of human airway smooth muscle cells following β2 adrenergic receptor desensitization. Deeney BT, Cao G, Orfanos S, Lee J, Kan M, Himes BE, Parikh V, Koziol-White CJ, An SS, Panettieri RA Jr.Am J Physiol Lung Cell Mol Physiol. 2022 Aug 1;323(2):L142-L151. doi: 10.1152/ajplung.00444.2021. Epub 2022 Jul 5.PMID: 35787178
  7. Airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma. Guidi R, Xu D, Choy DF, Ramalingam TR, Lee WP, Modrusan Z, Liang Y, Marsters S, Ashkenazi A, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Leong L, Cook A, Tran TH, Austin CD, Cao Y, Clarke C, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Wang F, Wilson MS.Sci Transl Med. 2022 Apr 20;14(641):eabl8146. doi: 10.1126/scitranslmed.abl8146. Epub 2022 Apr 20. PMID: 35442706.
  8. Airway smooth muscle and airway hyperresponsiveness in asthma – mechanisms of airway smooth muscle dysfunction  Gebski EB, Anaspure O, Panettieri RA,Koziol-White CJ. Minerva Med. 2022 Feb;113(1):4-16. DOI: 10.23736/S0026-4806.21.07283-9. Epub 2021 Jan 26. PMID: 33496164. ​
  9. Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma. Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, Hambro Sh, Nunez V, Klementowicz JE, Shi Y, Wang J, Bevers J III, Ramirez-Carrozzi V, Pappu R, Abbas A, Vander-Heiden J, Choy DF, Yadav R, Modrusan Z, Panettieri RA Jr., Koziol-White C, Jester WF Jr., Jenkins BJ, Cao Y, Clarke C, Austin C, Lafkas D, Xu M, Wolters PJ, Arron JR, West NR, Wilson MS. Science Translational Medicine 14, eabf8188 (2022) 12 January 2022.
  10. Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation.  Cao G, Lam H, Jude JA, Karmacharya N, Kan M, Jester W, Koziol-White C, Himes BE, Chupp GL, An SS, Panettieri RA Jr. Am J Respir Cell Mol Biol 2021 Oct 14.  Online ahead of print. doi: 10.1165/rcmb.2021-0345OC.PMID: 34648729.