Omar Tliba, Ph.D.

Omar Tliba

Associate Professor 
Division of Pulmonary and Critical Care Medicine
Robert Wood Johnson Medical School
 
Rutgers In
stitute for Translational Medicine and Science
Child Health Institute of New Jersey  
Rutgers, The State University of New Jersey 
89 French Street       

New Brunswick, NJ 08901  

Fax: (732) 235-7178

Email: ot62@ca.rutgers.edu

Education: 
Ms, Biomedical Sciences, University of Rennes I, France
Ms, Immunology, Institut pasteur, Paris
Ph.D., Immunology, University of Francois Rabellais, Tours, France

Postdoctoral Fellowship:
University of Pennsylvania, Philadelphia, PA

The recent therapeutic benefit in severe asthmatics provided by bronchial thermoplasty, a therapy that attenuates bronchoconstriction via reduction of airway smooth muscle (ASM) mass, has strongly supported the notion that ASM is a key player in the pathogenesis of asthma. ASM could also participate in the progression of asthma by secreting pro-inflammatory mediators reported both in cultured cells and in bronchial biopsies. My research interest includes airway smooth muscle biology, glucocorticoid signaling, and glucocorticoid resistance. Current research efforts are focused in four major areas:


Selected publications

  1. O'Connell D, Bouazza B, Kokalari B, Amrani Y, Khatib A, Ganther JD, Tliba O.  IFN-?-induced JAK/STAT, but not NF-KB, signaling pathway is insensitive to glucocorticoid in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L348-59

  2. Chachi L, Gavrila A, Tliba O, Amrani Y.  Abnormal corticosteroid signalling in airway smooth muscle: mechanisms and perspectives for the treatment of severe asthma.  Clin Exp Allergy. 2015 Nov;45(11):1637-46.

  3. Gavrila A, Chachi L, Tliba O, Brightling C, Amrani Y.  Effect of the plant derivative Compound A on the production of corticosteroid-resistant chemokines in airway smooth muscle cells.  Am J Respir Cell Mol Biol. 2015 Nov;53(5):728-37.

  4. Bouazza B, Debba-Pavard M, Amrani Y, Isaacs L, O'Connell D, Ahamed S, Formella D, Tliba O.  Basal p38 mitogen-activated protein kinase regulates unliganded glucocorticoid receptor function in airway smooth muscle cells.  Am J Respir Cell Mol Biol. 2014 Feb;50(2):301-15.

  5. Chachi L, Shikotra A, Duffy SM, Tliba O, Brightling C, Bradding P, Amrani Y.  Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells. J Immunol. 2013 Sep 1;191(5):2624-36.

  6. Bouazza B, Krytska K, Debba-Pavard M, Amrani Y, Honkanen RE, Tran J, Tliba OCytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases.  Am J Respir Cell Mol Biol. 2012 Oct;47(4):464-73.

  7. Durham A, Adcock IM, Tliba OSteroid resistance in severe asthma: current mechanisms and future treatment.  Curr Pharm Des. 2011;17(7):674-84. Review.

  8. Damera G, Fogle HW, Lim P, Goncharova EA, Zhao H, Banerjee A, Tliba O, Krymskaya VP, Panettieri RA Jr.  Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1.  Br J Pharmacol. 2009 Nov;158(6):1429-41.

  9. Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba OGlucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells.  Am J Respir Cell Mol Biol. 2010 Jan;42(1):9-15.

  10. Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.  Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis.  Mol Pharmacol. 2009 Oct;76(4):766-77.